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Oral Drugs Related With Muscle Wasting and Sarcopenia

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published by Ariadna Riera

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Oral drugs related with muscle wasting and sarcopenia. A review.

LL. campins; M Camps; A. Riera; E. Pleguezuelos; JC. Yebenes; M. Serra-Prat

Article:

What is SARCOPENIA? Experts definition.

"age-associated loss of skeletal muscle mass and function"

International Working Group on Sarcopenia.

"a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength  with a rise of adverse outcomes such as  disability, poor quality of life and death"

European Working Group on Sarcopenia in Older People (EWGSOP).

Immobility

Genetic influence

Inflamation

Nutricional deficiencies

Endocrine factors

SARCOPENIA

most important causes

Muscle atrophy occurs  when the rate of degradation exceeds the rate of muscle protein synthesis. Many drugs taken  regularly for common conditions may interact with some of these mechanisms, and may lead a harmful or beneficial effect on muscle mass and strength.

ORAL DRUGS associated to muscle function.

HARMFUL

BENEFICIAL

Statins

Sulfonylureas

Glinides

ACE inhibitors*  ARBs**

Biguanides Thiazolidinediones Incretines

Allopurinol Formeterol

Vitamin D

* ACE: angiotensin-converting enzims **ARBs: angiotensin receptor blockers

Key words: Sarcopenia-Muscle wasting- Angiotensin converting enzim inhibitors-Statins- Antidiabetic drugs - Vitamin D

Reference: Pharmacology 2017;99:1-8. DOI: 10.1159/000448247

Corresponding autor: Dr Lluis Campins [email protected]

Autor: @ricastariad