Oral drugs related with muscle wasting and sarcopenia. A review.
LL. campins; M Camps; A. Riera; E. Pleguezuelos; JC. Yebenes; M. Serra-Prat
What is SARCOPENIA? Experts definition.
"age-associated loss of skeletal muscle mass and function"
International Working Group on Sarcopenia.
"a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength with a rise of adverse outcomes such as disability, poor quality of life and death"
European Working Group on Sarcopenia in Older People (EWGSOP).
most important causes
Muscle atrophy occurs when the rate of degradation exceeds the rate of muscle protein synthesis. Many drugs taken regularly for common conditions may interact with some of these mechanisms, and may lead a harmful or beneficial effect on muscle mass and strength.
ORAL DRUGS associated to muscle function.
ACE inhibitors* ARBs**
Biguanides Thiazolidinediones Incretines
* ACE: angiotensin-converting enzims **ARBs: angiotensin receptor blockers
Key words: Sarcopenia-Muscle wasting- Angiotensin converting enzim inhibitors-Statins- Antidiabetic drugs - Vitamin D
Reference: Pharmacology 2017;99:1-8. DOI: 10.1159/000448247
Corresponding autor: Dr Lluis Campins [email protected]